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  • Pathophysiology of Diabetes Mellitus

    By Kindred Healthcare

    As we learn more about the pathophysiology of diabetes mellitus, we find that there is more yet to be discovered. Diabetes mellitus is a syndrome with disordered metabolism and inappropriate hyperglycemia due to either a deficiency of insulin secretion or to a combination of insulin resistance and inadequate insulin secretion to compensate. Type 1 diabetes is due to pancreatic islet B cell destruction predominantly by an autoimmune process, and these persons are prone to ketoacidosis. While type 2 diabetes is the more prevalent form and results from insulin resistance with a defect in compensatory insulin secretion. Diabetes can lead to serious complications, resulting in multiple diseases or disorders that affect multiple systems that may result in premature death.

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